John Krasinski kicked off the latest edition of Mean Tweets on last night's (Nov. 21) 'Jimmy Kimmel Live!' with the innocent question, "Can tweets even be mean?"

Yeah, the former 'Office' star found out pretty quickly how mean it could get: "your face is so stupid i hate you @johnkrasinski," a sadder-by-the-second Krasinski read aloud to the camera. Amy Poehler, Aaron Paul, Jason Biggs and Nick Offerman also appear in the segment, the fifth installment of the late-night show's popular feature showing that celebrities are people, too.

But 'Veep' actress and former 'Seinfeld' star Julia Louis-Dreyfuss steals the spotlight with her very amusing (and amused) response to her own over-the-top Twitter critic. Watch it above!